Use with other corticosteroids could increase the risk of side effects. Antacids can cause glucocorticoid absorption. Anticholinesterase use in patients with myasthenia gravis can cause muscle weakness. Use with diuretics can cause hypokalemia as a result of excessive potassium depletion. Estrogen agents may increase the effects of depo medrol. Use with macrolide antibiotics might lead to an increase in glucocorticoid activity and longevity. NSAID type drugs are not to be given to patients taking depo medrol. Taking with ulcerogenic drugs may increase the likelihood of a GI ulcer. Live attenuated virus vaccines should not be given at the same time as depo medrol, since the replication of the virus might be augmented.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor immediately if you develop symptoms of high blood sugar, such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program, or diet. This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat, cough, white patches in the mouth). Tell your doctor right away if you have any serious side effects, including: unusual weight gain, menstrual period changes, bone/joint pain, easy bruising/bleeding, mental/mood changes (such as mood swings, depression, agitation), muscle weakness/pain, puffy face, slow wound healing, swelling of the ankles/feet/hands, thinning skin, unusual hair/skin growth, vision problems, fast/slow/irregular heartbeat. This drug may infrequently cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, consult your doctor or pharmacist immediately: black/bloody stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds. Get medical help right away if you have any very serious side effects, including: seizures. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Read the entire patient information overview for Depo Medrol (Methylprednisolone Acetate Injectable Suspension)