MGA was first synthesized, in 1959, from medroxyprogesterone acetate, which itself had been synthesized the year prior in 1958.  MGA in combination with ethinylestradiol (EE) was introduced in 1963 by British Drug Houses in the United Kingdom under the brand name Volidan (4 mg MGA and 50 μg EE tablets) as an oral contraceptive ,   and this was followed by Serial 28 (1 mg MGA and 100 μg EE tablets) and Volidan 21 (4 mg MGA and 50 μg EE tablets) in 1964 and Nuvacon (2 mg MGA and 100 μg EE tablets) in 1967, all by British Drug Houses also in the .  MGA was approved in 1967 for the treatment of breast cancer.   In the 1970s, it was found to be associated with mammary tumors in beagle dogs, and along with several other progestogens, was withdrawn from several markets as an oral contraceptive.  Subsequent research revealed that there is no similar risk in humans. 
In February 2009, Sports Illustrated reported that Alex Rodriguez tested positive for two AAS, testosterone and metenolone enanthate, while playing for the Texas Rangers in 2003. He claims to have purchased them over the counter, in the Dominican Republic . However, " boli ," as he referred to it, is an illegal substance in the Dominican Republic.   In an interview with ESPN two days after the SI revelations, Rodriguez admitted to using banned substances from 2001 to 2003, citing "an enormous amount of pressure to perform," but said he had not since then used banned performance-enhancing substances.   He said he did not know the name(s) of the particular substance(s) he was using, and would not specify whether he took them in injectable form. 
Primobolan is required to be stored at a controlled room temperature of 20° to 25°C (68° to 77°F) with excursions permitted to 15° to 30°C (59° to 86°F). This anabolic steroid should be kept away from unauthorized use, pets, sunlight, moisture, and children. This steroid should not be flushed down the toilet or poured into a drain. Primobolan injections, capsules, or pills should be discarded after having a word with a pharmacist or local waste disposal company on how to safely discard Primobolan in case of expired Primobolan tablets or if the tablets or injections are not to be used any more.