Casing rules determine how to change the capitalization of a Unicode character; for example, from lowercase to uppercase. Often, a casing operation is performed before a string comparison. For example, a string might be converted to uppercase so that it can be compared with another uppercase string. You can convert the characters in a string to lowercase by calling the ToLower or ToLowerInvariant method, and you can convert them to uppercase by calling the ToUpper or ToUpperInvariant method. In addition, you can use the TextInfo . ToTitleCase method to convert a string to title case.
In humans, levels of 5-HT 1A receptor activation in the brain show negative correlation with aggression,  and a mutation in the gene that codes for the 5-HT 2A receptor may double the risk of suicide for those with that genotype.  Serotonin in the brain is not usually degraded after use, but is collected by serotonergic neurons by serotonin transporters on their cell surfaces. Studies have revealed nearly 10% of total variance in anxiety-related personality depends on variations in the description of where, when and how many serotonin transporters the neurons should deploy.