The major portion of the antifreeze coolant concentrate (., 75%-% (by weight), preferably 90%-% (by weight)) comprises a liquid alcohol freezing point depressant. Suitable liquid alcohol freezing point depressants include any alcohol or heat transfer medium capable of use as a heat transfer fluid and preferably is at least one alcohol, selected from the group consisting of methanol, ethanol, propanol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, glycerol, the monethylether of glycerol, the dimethylether of glycerol, alkoxy alkanols (such as methoxyethanol) and mixtures thereof. The preferred alcohol is selected from the group consisting of ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol and mixtures thereof.
Lauric acid increases total serum cholesterol more than many other fatty acids. But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol). As a result, lauric acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid [examined], either saturated or unsaturated".  In general, a lower total/HDL serum cholesterol ratio correlates with a decrease in atherosclerotic risk.  Nonetheless, an extensive meta-analysis on foods affecting the total/ LDL serum cholesterol ratio found in 2003 that the net effects of lauric acid on coronary artery disease outcomes remained uncertain.  A 2016 review of coconut oil (which is nearly half lauric acid) was similarly inconclusive about the effects on cardiovascular disease risk.